CDK12/13-IN-2
CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12/13, with IC50 values of 15.5 nM and 12.2 nM for CDK12 and CDK13, respectively. CDK12/13-IN-2 can inhibit the proliferation of breast cancer cells and can be used in the research of triple-negative breast cancer[1].
Product Specifications
CAS Number
3076450-41-1
UNSPSC
12352005
Target
CDK
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
C=CC(NC1=CC=C(C2=NN3C(C=C2)=NC(CC(NC4=NNC(C5CCC5)=C4)=O)=C3)C=C1F)=O
Molecular Formula
C24H22FN7O2
Molecular Weight
459.48
References & Citations
[1]Xia M, Li Z, et al. Discovery of novel imidazo[1,2-b]pyridazine derivatives as potent covalent inhibitors of CDK12/13. Eur J Med Chem. 2025 Apr 15;288:117378.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12; CDK13
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LC402493 20 µg
Isochorismatase domain containing protein 1 (ISOC1) (NM_016048) Human Over-expression Lysate
Sign In for Pricing
View Details 
BNC470781-100 1x 100 µL
Carbonic Anhydrase IX (CA9/781), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details