CDK12/13-IN-2

CDK12/13-IN-2 (Compound 24) is a covalent inhibitor of CDK12/13, with IC50 values of 15.5 nM and 12.2 nM for CDK12 and CDK13, respectively. CDK12/13-IN-2 can inhibit the proliferation of breast cancer cells and can be used in the research of triple-negative breast cancer[1].

Product Specifications

CAS Number

[3076450-41-1]

UNSPSC

12352005

Target

CDK

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

C=CC(NC1=CC=C(C2=NN3C(C=C2)=NC(CC(NC4=NNC(C5CCC5)=C4)=O)=C3)C=C1F)=O

Molecular Formula

C24H22FN7O2

Molecular Weight

459.48

References & Citations

[1]Xia M, Li Z, et al. Discovery of novel imidazo[1,2-b]pyridazine derivatives as potent covalent inhibitors of CDK12/13. Eur J Med Chem. 2025 Apr 15;288:117378.