α-Tubulin polymerization-IN-1

α-Tubulin polymerization-IN-1 (Compound 8l) is an inhibitor for α-Tubulin polymerization. α-Tubulin polymerization-IN-1 modulates the NRF2/KEAP-1 signaling pathway, induces ROS generation in PC-3 cell, thereby inducing apoptosis in PC-3. α-Tubulin polymerization-IN-1 inhibits the proliferation of PC-3 cell with a GI50 of 0.17 µM, arrests the cell cycle at G2/M phase. α-Tubulin polymerization-IN-1 exhibits antitumor efficacy in mouse model[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Keap1-Nrf2; Microtubule/Tubulin; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

CC(N[C@H](C1=C2)CCC3=CC(OC)=C(OC)C(OC)=C3C1=CC=C(N[C@@H](C4=CC=CC=C4)C)C2=O)=O

Molecular Formula

C29H32N2O5

Molecular Weight

488.57

References & Citations

[1]Reddy CN, et al., 7S,15R-Stereoisomer of phenylethylamino derivative of colchicine exhibits potent in-vitro and in-vivo anti-cancer activity against prostate Cancer: Assessing the impact of stereochemistry on biological activity. Bioorg Chem. 2025 Apr;157:108262.