PTP1B-IN-30
PTP1B-IN-30 (Compound 3j) is the inhibitor for PTP1B with an IC50 of 0.51 µM. PTP1B-IN-30 inhibits the proliferation of cancer cell T47D with an IC50 of 21.21 µM, arrests the cell cycle at S phase, and induces apoptosis in T47D[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Phosphatase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(OC)C1=CC(/C(C)=N/NC2=NC(C3=CC=C4OCCCOC4=C3)=CS2)=CC=C1O
Molecular Formula
C22H21N3O5S
Molecular Weight
439.48
References & Citations
[1]Kołodziej-Sobczak D, et al., Design, synthesis, molecular docking and anticancer activity evaluation of methyl salicylate based thiazoles as PTP1B inhibitors. Sci Rep. 2025 Feb 10;15 (1) :4892.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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