UAMC-4821
UAMC-4821 is an inhibitor for ferroptosis with an IC50 of 5.2 nM. UAMC-4821 scavenges free radicals, blocks the lipid peroxidation, inhibits ML162 (HY-100002) -induced ferroptosis, and exhibits protective effect in HT-1080 cell. UAMC-4821 exhibits good pharmacokinetics characteristics in mouse with an oral bioavailability of 63%. UAMC-4821 can cross blood-brain barrier[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC1=CC(C2=CN=CO2)=CC=C1NC3CCCCC3
Molecular Formula
C15H19N3O
Molecular Weight
257.33
References & Citations
[1]Scarpellini C, et al., Oxazole-Based Ferroptosis Inhibitors with Promising Properties to Treat Central Nervous System Diseases. J Med Chem. 2025 Feb 27;68 (4) :4908-4928.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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