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UAMC-4821

UAMC-4821 is an inhibitor for ferroptosis with an IC50 of 5.2 nM. UAMC-4821 scavenges free radicals, blocks the lipid peroxidation, inhibits ML162 -induced ferroptosis, and exhibits protective effect in HT-1080 cell. UAMC-4821 exhibits good pharmacokinetics characteristics in mouse with an oral bioavailability of 63%. UAMC-4821 can cross blood-brain barrier[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

NC1=CC(C2=CN=CO2)=CC=C1NC3CCCCC3

Molecular Formula

C15H19N3O

Molecular Weight

257.33

References & Citations

[1]Scarpellini C, et al., Oxazole-Based Ferroptosis Inhibitors with Promising Properties to Treat Central Nervous System Diseases. J Med Chem. 2025 Feb 27;68 (4) :4908-4928.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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