SPB07935
SPB07935 inhibits the plasmepsin II in Plasmodium falciparum and can be used as an antimalarial agent. SPB07935 regulates the life cycle of P. falciparum, inhibits the growth of Plasmodium strains FcB1 and 3D7 with IC50 of 8 μM and 4.7 μM[1].
Product Specifications
CAS Number
634190-75-3
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=[N+]([O-])C1=CN=C(S1)SC2=NN=C(C3=CC=CO3)N2C(C=C4)=CC=C4OCC5=CC=CC=C5
Molecular Formula
C22H15N5O4S2
Molecular Weight
477.52
References & Citations
[1]Valiente PA, et al., Discovery of a Noncompetitive Open-Flap Selective Inhibitor of Plasmepsin II with Antiplasmodial Activity. J Chem Inf Model. 2025 Feb 24;65 (4) :2038-2051.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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