Nurr1 agonist 12
Nurr1 agonist 12 (Compound 37) is the agonist for nuclear receptor-associated protein 1 (Nurr1) that activates the transcriptional activity of Nurr1 with an EC50 of 0.06 μM. Nurr1 agonist 12 activates the human response elements NBRE, NurRE, and DR5 with EC50 of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Nurr1 agonist 12 induces the expression of Nurr1-regulated neurotrophic genes, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin) . Nurr1 agonist 12 exhibits neuroprotective efficacy against Paraquat-induced neurotoxicity[1].
Product Specifications
UNSPSC
12352005
Target
Nuclear Hormone Receptor 4A/NR4A
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=C(Cl)C=C2C=CNC2=C1)NC3=CC4=C(C=CC=C4)N=C3
Molecular Formula
C18H12ClN3O
Molecular Weight
321.76
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nurr1/NR4A2
Available Sizes
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