IDOi-Pt (IV) prodrug-1
IDOi-Pt (IV) prodrug-1 (Compound 10) is an IDOi-Pt (IV) prodrug. IDOi-Pt (IV) prodrug-1 inhibits IDO expression. IDOi-Pt (IV) prodrug-1 induces apoptosis, decreases the mitochondrial membrane potential, inhibits tumor cell migration and invasion. IDOi-Pt (IV) prodrug-1 induces reactive oxygen species-mediated endoplasmic reticulum stress and secretion of damage-associated molecular patterns (DAMPs), thereby presenting immunogenic cell death (ICD) effects. IDOi-Pt (IV) prodrug-1 has high-efficiency and low-toxicity antitumor effects compared to Cisplatin.
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Indoleamine 2,3-Dioxygenase (IDO) ; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
[NH3][Pt](Cl)(Cl)(O)([NH3])OC(CCCC(N1C2=CC=C(C=C2C(SC3=CC(OC)=CC(OC)=C3)=C1)Cl)=O)=O
Molecular Formula
C21H26Cl3N3O6PtS
Molecular Weight
749.96
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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