HINT1-IN-1
HINT1-IN-1 (Compound 8) is the inhibitor for histidine triad nucleotide-binding protein 1 (HINT1) with a Ki of 1.14 μM. HINT1-IN-1 affects the cross-regulation between μ-opioid receptor (MOR) and NMDA receptor (NMDAR) . HINT1-IN-1 enhances the analgesic effect of morphine without causing opioid tolerance and has independent analgesic effects in mouse model[1].
Product Specifications
UNSPSC
12352005
Target
Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)N3C4=NC=C3)=C4N=C2)O1)NCCC5=CNC6=C5C=CC=C6
Molecular Formula
C23H24N8O5
Molecular Weight
492.49
References & Citations
[1]Dillenburg M, et al., HINT1 Inhibitors as Selective Modulators of MOR-NMDAR Cross-Regulation and Non-Opioid Analgesia. ACS Chem Neurosci. 2025 Feb 19;16 (4) :604-618.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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