CypA ligand-2
CypA ligand-2 is the target protein ligand of PROTAC RJS308 (HY-173011) . RJS308 is a PROTAC targeting CypA and exhibits antiviral activity[1].
Product Specifications
UNSPSC
12352005
Target
Cyclophilin; Ligands for Target Protein for PROTAC
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Infection
Smiles
O=C1N2N[C@@H](CCC2)C(O[C@H](C)C3=CC=C4C(C=C(C=C4)/C=C/CC(N[C@H](C(N[C@H]1CC#C)=O)CC5=CC=C([N+]([O-])=O)C=C5)=O)=N3)=O
Molecular Formula
C34H34N6O7
Molecular Weight
638.67
References & Citations
[1]Newton LS, et al. Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16 (1) :1484.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cyclophilin A
Available Sizes
Curated Selection
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