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RJS308

RJS308 is the PROTAC degrader for cyclosporin A (CypA) with a DC50 of 284 nM. RJS308 exhibits antiviral activcity through inhibition of HIV-1 and HCV replication[1]. (Pink: ligand for target protein CypA ligand-2 (HY-173012) ; Black: linker (HY-W123015) ; Blue: ligand for E3 ligase VHL (S, R, S) -AHPC-Me (HY-112078) )

Product Specifications

UNSPSC

12352005

Target

Cyclophilin; HCV; HIV; PROTACs

Related Pathways

Anti-infection; Immunology/Inflammation; PROTAC

Applications

COVID-19-anti-virus

Field of Research

Infection

Purity

98.87

Smiles

C[C@@H](C1=CC=C(C2=C(C)N=CS2)C=C1)NC([C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCN4N=NC(C[C@H]5C(N6N[C@@H](CCC6)C(O[C@H](C)C7=CC=C8C(C=C(C=C8)/C=C/CC(N[C@H](C(N5)=O)CC9=CC=C([N+]([O-])=O)C=C9)=O)=N7)=O)=O)=C4)=O)=O)=O

Molecular Formula

C63H75N13O11S

Molecular Weight

1222.42

References & Citations

[1]Newton LS, et al., Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16 (1) :1484.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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