RJS308
RJS308 is the PROTAC degrader for cyclosporin A (CypA) with a DC50 of 284 nM. RJS308 exhibits antiviral activcity through inhibition of HIV-1 and HCV replication[1]. (Pink: ligand for target protein CypA ligand-2 (HY-173012) ; Black: linker (HY-W123015) ; Blue: ligand for E3 ligase VHL (S, R, S) -AHPC-Me (HY-112078) )
Product Specifications
UNSPSC
12352005
Target
Cyclophilin; HCV; HIV; PROTACs
Related Pathways
Anti-infection; Immunology/Inflammation; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Infection
Purity
98.87
Smiles
Molecular Formula
C63H75N13O11S
Molecular Weight
1222.42
References & Citations
[1]Newton LS, et al., Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16 (1) :1484.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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