RJS308
RJS308 is the PROTAC degrader for cyclosporin A (CypA) with a DC50 of 284 nM. RJS308 exhibits antiviral activcity through inhibition of HIV-1 and HCV replication[1]. (Pink: ligand for target protein CypA ligand-2 ; Black: linker (HY-W123015) ; Blue: ligand for E3 ligase VHL (S, R, S) -AHPC-Me (HY-112078) )
Product Specifications
UNSPSC
12352005
Target
Cyclophilin; HCV; HIV; PROTACs
Related Pathways
Anti-infection; Immunology/Inflammation; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Infection
Purity
98.87
Smiles
C[C@@H](C1=CC=C(C2=C(C)N=CS2)C=C1)NC([C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCN4N=NC(C[C@H]5C(N6N[C@@H](CCC6)C(O[C@H](C)C7=CC=C8C(C=C(C=C8)/C=C/CC(N[C@H](C(N5)=O)CC9=CC=C([N+]([O-])=O)C=C9)=O)=N7)=O)=O)=C4)=O)=O)=O
Molecular Formula
C63H75N13O11S
Molecular Weight
1222.42
References & Citations
[1]Newton LS, et al., Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16 (1) :1484.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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