ALK/PI3K/AKT-IN-1
ALK/PI3K/AKT-IN-1 (Compound 45) inhibits the proliferation of cancer cell A549, H1975 and PC9 with an IC50 of 0.44, 0.83 and 1.51 μM. ALK/PI3K/AKT-IN-1 increases the expression of p21 and p27, inhibits the activity of CDK2 and p-Rb, arrests the cell cycle at G1 phase. ALK/PI3K/AKT-IN-1 inhibits the ALK/PI3K/AKT signaling pathway, promotes the depolarization of mitochondrial membrane potential, and inducing apoptosis in A549 cell. ALK/PI3K/AKT-IN-1 inhibits the formation and growth of A549 cell spheroids[1].
Product Specifications
CAS Number
[3050831-84-7]
UNSPSC
12352005
Target
Akt; Anaplastic lymphoma kinase (ALK) ; Apoptosis; CDK; Mitochondrial Metabolism; PI3K
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC1=NC2=CC(C3=CC4=C(N=CN(CCC)C4=O)C=C3)=CC=C2S1)NC5=CC=C(F)C=C5
Molecular Formula
C25H20FN5O2S
Molecular Weight
473.52
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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