MS9024
MS9024 is the degrader for DNA methyltransferase 1 that degrades DNMT1 in cell HCT116 through the ubiquitin-proteasome pathway with a DC50 of 35 nM (DC50 in MDA-MB-468 and H1299 is 254 nM and 101 nM) . MS9024 also inhibits DNMT1 with an IC50 of 0.43 μM[1].
Product Specifications
UNSPSC
12352005
Target
DNA Methyltransferase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.83
Solubility
DMSO : 8.33 mg/mL (ultrasonic)
Smiles
CCC1=C(C(SC(C2=CC=CC=C2)C(N)=O)=NC(N(CC(NC)=O)C)=C1C#N)C#N
Molecular Formula
C21H22N6O2S
Molecular Weight
422.50
References & Citations
[1]Qian C, et al., Structure-Activity Relationship Studies of DNA Methyltransferase 1 Monovalent Degraders. J Med Chem. 2025 Feb 13;68 (3) :2903-2919.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNMT1
Available Sizes
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