STAT3-IN-40
STAT3-IN-40 (Compound 8b) is an anti-cancer agent. STAT3-IN-40 can trigger the immune responses of CD4+ and CD8+ T lymphocytes and induce ferroptosis and apoptosis of tumor cells by inhibiting the expression and phosphorylation of STAT3. STAT3-IN-40 can be used in the research of chemoimmunotherapeutic agents for cancer[1].
Product Specifications
CAS Number
[3053241-01-0]
UNSPSC
12352005
Target
Apoptosis; Ferroptosis; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(N1C/C(C(/C(C1)=C/C2=CC=C(C=C2)[N+]([O-])=O)=O)=C\C3=CC=C(C=C3)[N+]([O-])=O)CCCC([O-][Pt+4]45([NH2][C@@]6([H])[C@](CCCC6)([H])[NH2]4)([O-]C(C([O-]5)=O)=O)[Cl-])=O
Molecular Formula
C32H34ClN5O12Pt
Molecular Weight
911.18
References & Citations
[1]Mao ZC, et al. Design, synthesis and evaluation of diarylidenyl piperidone-ligated platinum (IV) complexes as chemoimmunotherapeutic agents. Eur J Med Chem. 2025 Apr 5;287:117338.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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