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PTC-700

PTC-700 is a potent microtubule-associated protein tau (MAPT) splicing modulator. PTC-700 reduces 4R MAPT in both P301L and S305N neurons with EC50s of 1.3-1.8 nM, and 0.5-2.6 nM, respectively[1].

Product Specifications

CAS Number

2476726-76-6

UNSPSC

12352005

Target

Tau Protein

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CC1=C(SC2=C(C=C(N=C12)Cl)NCC3=NC=CS3)C[C@@H](N)C

Molecular Formula

C15H17ClN4S2

Molecular Weight

352.91

References & Citations

[1]Silva, M. Catarina, et al. MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies bioRxiv (2025) : 2025-05.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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