PTC-700
PTC-700 is a potent microtubule-associated protein tau (MAPT) splicing modulator. PTC-700 reduces 4R MAPT in both P301L and S305N neurons with EC50s of 1.3-1.8 nM, and 0.5-2.6 nM, respectively[1].
Product Specifications
CAS Number
[2476726-76-6]
UNSPSC
12352005
Target
Tau Protein
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC1=C(SC2=C(C=C(N=C12)Cl)NCC3=NC=CS3)C[C@@H](N)C
Molecular Formula
C15H17ClN4S2
Molecular Weight
352.91
References & Citations
[1]Silva, M. Catarina, et al. MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies bioRxiv (2025) : 2025-05.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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