Mitochondrial-IN-1

Mitochondrial-IN (C458) is a potent mitochondrial complex I inhibitor. Mitochondrial-IN demonstrates high protection against Aβ toxicity, favorable pharmacokinetics, and minimal off-target effects[1].

Product Specifications

CAS Number

[2001090-87-3]

UNSPSC

12352211

Target

Mitochondrial Metabolism

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Neurological Disease

Smiles

CC1=CC=CC(O[C@@H]2CCC[C@H](C(C)CNCC3=CC=NC=C3)C2)=C1

Molecular Formula

C22H30N2O

Molecular Weight

338.49

References & Citations

[1]Trushin S, et al. Therapeutic assessment of a novel mitochondrial complex I inhibitor in in vitro and in vivo models of Alzheimer's disease. bioRxiv [Preprint]. 2025 Mar 21:2025.02.12.637918.