HQY1428
HQY1428 is an orally active CDK12 inhibitor. HQY1428 inhibits DNA replication, causes G2/M arrest in SKOV3 cells, induces DNA double-strand breaks and apoptosis. HQY1428 has anti-tumor activity in the SKOV3 xenograft mouse model. HQY1428 combined with the HER2 inhibitor Lapatinib in the NCI-N87 xenograft mouse model produces a synergistic therapeutic effect[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; CDK; DNA/RNA Synthesis
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=C(C=CC=C1)NC2=C(C=NC(N[C@@H]3CCCN(C3)C(C4=CC(F)=CC(N)=C4)=O)=N2)Cl)(C(C)C)=O
Molecular Formula
C25H28ClFN6O3S
Molecular Weight
547.04
References & Citations
[1]Ye K, et al. CDK12 condensation in nuclear speckles confers sensitivity to cyclin K molecular glue degraders[J]. bioRxiv, 2025: 2025.03. 31.646293.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK12
Available Sizes
Frequently Asked Questions
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