ZHAWOC8655

ZHAWOC8655 is a USP18 inhibitor. ZHAWOC8655 compromises cellular USP18/ISG15 binding and inhibits USP18 protease activity in vitro[1].

Product Specifications

CAS Number

[1257657-02-5]

UNSPSC

12352005

Target

Deubiquitinase

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.63

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=CC=C2NC3=C(C2=C1)CN(CC3)C(C4=NNC(C5=CC=CC=C5)=C4)=O

Molecular Formula

C22H20N4O

Molecular Weight

356.42

References & Citations

[1]Hess, S., et al. A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding. bioRxiv, 2025-03.|[2]Hess, S., et al. A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding. bioRxiv, 2025-03.