ZHAWOC8655
ZHAWOC8655 is a USP18 inhibitor. ZHAWOC8655 compromises cellular USP18/ISG15 binding and inhibits USP18 protease activity in vitro[1].
Product Specifications
CAS Number
[1257657-02-5]
UNSPSC
12352005
Target
Deubiquitinase
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.63
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC1=CC=C2NC3=C(C2=C1)CN(CC3)C(C4=NNC(C5=CC=CC=C5)=C4)=O
Molecular Formula
C22H20N4O
Molecular Weight
356.42
References & Citations
[1]Hess, S., et al. A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding. bioRxiv, 2025-03.|[2]Hess, S., et al. A NanoBRET-based assay monitoring interactions in the USP18 signaling hub identifies the first cell-penetrant small molecule compromising USP18/ISG15 binding. bioRxiv, 2025-03.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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