KIM-161
KIM-161 is a PIK3CA inhibitor. KIM-161 has significant antiproliferative activity with IC50 values of 1.428 and 1.562 µM against PI3KCA mutant breast cancer MCF7 and T47D cells, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway and inducing ROS production. KIM-161 can be used to study breast cancer and its PI3KCA mutant subtypes[1].
Product Specifications
CAS Number
[2559686-28-9]
UNSPSC
12352211
Target
Akt; Apoptosis; mTOR; PI3K; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
O=C(NCC1=CC=CC=C1)CC2=CC=C(N3C(/C(N=C3C)=C/C4=CC=C(OC)C=C4)=O)C=C2
Molecular Formula
C27H25N3O3
Molecular Weight
439.51
References & Citations
[1]AlKharboush DF, et al. Exploring a kinase inhibitor targeting PI3KCA mutant cancer cells. J Biomol Struct Dyn. 2025 May 19:1-18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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