DNA Gyrase-IN-17

DNA Gyrase-IN-17 (Compound 5C) is a DNA Gyrase inhibitor. DNA Gyrase-IN-17 exhibits significant antibacterial activity against a variety of Gram-positive and Gram-negative strains (such as Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, etc.), with a MIC value of 62.5 μg/mL. DNA Gyrase-IN-17 interferes with DNA replication by inhibiting bacterial DNA gyrase. DNA Gyrase-IN-17 can be used in the development of antibacterial drugs, especially for the study of drug-resistant strains[1].

Product Specifications

UNSPSC

12352100

Target

Topoisomerase

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

OC(C)C1=NC2=CC=CC=C2N1CC3=CN(C4=CC=C(F)C=C4Cl)N=N3

Molecular Formula

C18H15ClFN5O

Molecular Weight

371.80

References & Citations

[1]Maurya A, et al. Design and synthesis of new benzimidazole-hybrids as anti-microbial agents: exploring the mechanistic insights as DNA gyrase inhibitors via in silico and in vitro based studies. J Biomol Struct Dyn. 2025 May 13:1-20.