JNN-5
JNN-5 is a potent and selective JAK2 inhibitor with an IC50 of 0.41 nM. JNN-5 shows strong antiproliferative activities in the TNBC cell lines (MDA-MB-468, MDA-MB-213, HCC70, MDA-MB-157) [1].
Product Specifications
UNSPSC
12352005
Target
JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
CC1=C(N=C(N=C1)NC2=CC3=C(CN(CC3)C(/C=C/C(C4=CC=C(C=C4)Cl)=O)=O)C=C2)C5=CN(N=C5)C(C)C
Molecular Formula
C30H29ClN6O2
Molecular Weight
541.04
References & Citations
[1]Miao Y, et al. Discovery and biological evaluation of a novel and highly potent JAK2 inhibitor for the treatment of triple negative breast cancer. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2488127.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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