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Androgen receptor ligand 1

Androgen receptor ligand 1 is an androgen receptor (AR) ligand. Androgen receptor ligand 1 binds to CRBN E3 ligase via a linker to form an AR PROTAC degrader. Androgen receptor ligand 1 can be used in the study of prostate cancer[1].

Product Specifications

CAS Number

3077430-87-3

UNSPSC

12352005

Target

Androgen Receptor; Ligands for Target Protein for PROTAC

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

FC1=C(C(F)(F)F)C(C#N)=CC=C1N(CC2)CCC2C3=CC=C(O)C=C3

Molecular Formula

C19H16F4N2O

Molecular Weight

364.34

References & Citations

[1]Bagal SK, et al. Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. J Med Chem. 2024 Jul 25;67 (14) :11732-11750.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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