Androgen receptor ligand 1
Androgen receptor ligand 1 is an androgen receptor (AR) ligand. Androgen receptor ligand 1 binds to CRBN E3 ligase via a linker to form an AR PROTAC degrader. Androgen receptor ligand 1 can be used in the study of prostate cancer[1].
Product Specifications
CAS Number
[3077430-87-3]
UNSPSC
12352005
Target
Androgen Receptor; Ligands for Target Protein for PROTAC
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
FC1=C(C(F)(F)F)C(C#N)=CC=C1N(CC2)CCC2C3=CC=C(O)C=C3
Molecular Formula
C19H16F4N2O
Molecular Weight
364.34
References & Citations
[1]Bagal SK, et al. Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer. J Med Chem. 2024 Jul 25;67 (14) :11732-11750.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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