Insecticidal agent 24
Insecticidal agent 24 is an orally active pyridylspiroindoline frontrunner. Insecticidal agent 24 has antiplasmodial activity (Pf NF54 IC50: 0.08 μM) . Insecticidal agent 24 inhibits hERG activity (IC50: 6.5 μM) . Insecticidal agent 24 reduces parasitemia in a humanized immunodeficient NSG mouse Plasmodium falciparum infection model[1].
Product Specifications
UNSPSC
12352005
Target
Parasite
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Smiles
COC1=CC2=C(N(C3=CC=NC=C3)CC24CCN(CC4)C)C=C1OCC5=CC=CC=C5
Molecular Formula
C26H29N3O2
Molecular Weight
415.53
References & Citations
[1]Dam J, et al. Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum. J Med Chem. 2025 May 22;68 (10) :10156-10172.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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