SD-2301

SD-2301 is a selective STAT3 PROTAC degrader. SD-2301 induces STAT3 degradation without affecting the protein levels of other STAT family members (STAT1, STAT2, STAT4, STAT5, STAT6) . SD-2301 exerts anti-tumor effects in B16F10-bearing mice. SD-2301 can be used for the study of cancer. (Pink: STAT3 ligand (HY-172947), Blue: VHL Ligand (HY-172948), Black: Linker (HY-W577012), VHL ligand-linker conjugate (HY-172949) ) [1].

Product Specifications

CAS Number

[3054116-24-1]

UNSPSC

12352005

Target

PROTACs; STAT

Related Pathways

JAK/STAT Signaling; PROTAC; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

O=C([C@@H](NC([C@@H]1CC[C@@H]2CCN(C[C@@H](C(N12)=O)NC(C3=CC4=C(N3)C=CC(C(P(O)(O)=O)=O)=C4)=O)C(CCCCC5=CN(N=N5)[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(N[C@H](C7=CC=C(C=C7)C8=C(N=CS8)C)C)=O)O)=O)=O)=O)CCC(N)=O)NCC(C=C9)=CC=C9S(=O)(CC)=O

Molecular Formula

C64H80N13O15PS2

Molecular Weight

1366.50

References & Citations

[1]Zhou J, et al. STAT5 and STAT3 balance shapes dendritic cell function and tumour immunity. Nature. 2025 May 14.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

STAT3; von Hippel-Lindau (VHL)

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

T8050-45E-PE 100 µL

TLR5 (Toll Like Receptor 5, Toll-like Receptor 5 Precursor, TLR 5, TLR-5, FLJ10052, MGC126430, MGC126431, Toll/interleukin 1 Receptor-like Protein 3, TIL3) (PE) discontinued

Ask

View Details

MR217188L3 10 µg

EmL1 (NM_001043335) Mouse Tagged Lenti ORF Clone

Ask

View Details

035285 200 µL

EYA4, CT (EYA4, Eyes absent homolog 4)

Ask

View Details