PLK1/PRC1-IN-1

PLK1/PRC1-IN-1 (compound B4) is a PLK1/PRC1 protein complex formation inhibitor. PLK1/PRC1-IN-1 can be used in the study of non-small cell lung cancer (NSCLC) [1].

Product Specifications

CAS Number

[2991469-28-2]

UNSPSC

12352211

Target

Polo-like Kinase (PLK)

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CN(CCN1C(C2=CC=CC3=C(C=CC(C1=O)=C23)S(=O)(NCC4=CC=C(C=C4)C(F)(F)F)=O)=O)C

Molecular Formula

C24H22F3N3O4S

Molecular Weight

505.51

References & Citations

[1]Li P, et al. Pharmacological inhibition of PLK1/PRC1 triggers mitotic catastrophe and sensitizes lung cancers to chemotherapy. Cell Death Dis. 2025 May 12;16 (1) :374.