PLK1/PRC1-IN-1
PLK1/PRC1-IN-1 (compound B4) is a PLK1/PRC1 protein complex formation inhibitor. PLK1/PRC1-IN-1 can be used in the study of non-small cell lung cancer (NSCLC) [1].
Product Specifications
CAS Number
2991469-28-2
UNSPSC
12352211
Target
Polo-like Kinase (PLK)
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CN(CCN1C(C2=CC=CC3=C(C=CC(C1=O)=C23)S(=O)(NCC4=CC=C(C=C4)C(F)(F)F)=O)=O)C
Molecular Formula
C24H22F3N3O4S
Molecular Weight
505.51
References & Citations
[1]Li P, et al. Pharmacological inhibition of PLK1/PRC1 triggers mitotic catastrophe and sensitizes lung cancers to chemotherapy. Cell Death Dis. 2025 May 12;16 (1) :374.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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