SP11
SP11 is a mitochondrial reactive oxygen species (ROS) inhibitor. SP11 activates Fis1 by binding to Cys41 (IC50: 9.4 µM) and increases the translocation of Drp1 to mitochondria. SP11 can be used in studies on the protection against oxidative stress damage[1].
Product Specifications
CAS Number
[2629218-24-0]
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Purity
98.91
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CN(C(CCl)=O)CCCN1C2=CC=CC=C2SC3=C1C=CC=C3
Molecular Formula
C18H19ClN2OS
Molecular Weight
346.87
References & Citations
[1]Pokhrel S, et al. A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress. Nat Commun. 2025 May 6;16 (1) :4187.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-172942/SP11-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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