SP11

SP11 is a mitochondrial reactive oxygen species (ROS) inhibitor. SP11 activates Fis1 by binding to Cys41 (IC50: 9.4 µM) and increases the translocation of Drp1 to mitochondria. SP11 can be used in studies on the protection against oxidative stress damage[1].

Product Specifications

CAS Number

[2629218-24-0]

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Purity

98.91

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CN(C(CCl)=O)CCCN1C2=CC=CC=C2SC3=C1C=CC=C3

Molecular Formula

C18H19ClN2OS

Molecular Weight

346.87

References & Citations

[1]Pokhrel S, et al. A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress. Nat Commun. 2025 May 6;16 (1) :4187.