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VEN-02XX

VEN-02XX is an orally active and brain-permeable NLRP3 inhibitor. VEN-02XX inhibits the release of IL-1β and IL-18 (IC50 0.3 and 0.28 μM, respectively) . VEN-02XX restores memory and cognition, inhibits microgliosis, and reduces neuroinflammation and tau pathology in the 5XFAD/Rubicon KO mouse model. VEN-02XX may be used in the study of Alzheimer's disease (AD) [1].

Product Specifications

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation

Field of Research

Neurological Disease

Purity

99.6600

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(O)(CNC1=C2C=NC=CC2=C(N=N1)C3=CC=C(C=C3C(F)(F)F)Cl)C

Molecular Formula

C18H16ClF3N4O

Molecular Weight

396.79

References & Citations

[1]Auger A, et al. Post-symptomatic NLRP3 inhibition rescues cognitive impairment and mitigates amyloid and tau driven neurodegeneration. NPJ Dement. 2025;1 (1) :3.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NLRP3

Available Sizes

Frequently Asked Questions

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