VEN-02XX
VEN-02XX is an orally active and brain-permeable NLRP3 inhibitor. VEN-02XX inhibits the release of IL-1β and IL-18 (IC50 0.3 and 0.28 μM, respectively) . VEN-02XX restores memory and cognition, inhibits microgliosis, and reduces neuroinflammation and tau pathology in the 5XFAD/Rubicon KO mouse model. VEN-02XX may be used in the study of Alzheimer's disease (AD) [1].
Product Specifications
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Neurological Disease
Purity
99.6600
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(O)(CNC1=C2C=NC=CC2=C(N=N1)C3=CC=C(C=C3C(F)(F)F)Cl)C
Molecular Formula
C18H16ClF3N4O
Molecular Weight
396.79
References & Citations
[1]Auger A, et al. Post-symptomatic NLRP3 inhibition rescues cognitive impairment and mitigates amyloid and tau driven neurodegeneration. NPJ Dement. 2025;1 (1) :3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Available Sizes
Frequently Asked Questions
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