FR-β ligand 1
FR-β ligand 1 (III), a folate receptor-targeting ligand, possesses antitumor activity, high selectivity, and stronger affinity for folate receptor[1].
Product Specifications
CAS Number
[863869-78-7]
UNSPSC
12352211
Target
Antifolate
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC(NC1=O)=NC2=C1C=C(CCCCC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)N2
Molecular Formula
C22H25N5O6
Molecular Weight
455.46
References & Citations
[1]Lixiao Guo, et al. Design and Synthesis of FR-β Targeting Chimeric Molecules for Reprogramming Tumor-Associated Macrophages Using 6-Substituted Pyrrolo[2,3- d]pyrimidines as Targeting Ligands. J Med Chem. 2025 Apr 24;68 (8) :8295-8309.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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