FR-β ligand 1

FR-β ligand 1 (III), a folate receptor-targeting ligand, possesses antitumor activity, high selectivity, and stronger affinity for folate receptor[1].

Product Specifications

CAS Number

[863869-78-7]

UNSPSC

12352211

Target

Antifolate

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

NC(NC1=O)=NC2=C1C=C(CCCCC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)N2

Molecular Formula

C22H25N5O6

Molecular Weight

455.46

References & Citations

[1]Lixiao Guo, et al. Design and Synthesis of FR-β Targeting Chimeric Molecules for Reprogramming Tumor-Associated Macrophages Using 6-Substituted Pyrrolo[2,3- d]pyrimidines as Targeting Ligands. J Med Chem. 2025 Apr 24;68 (8) :8295-8309.