FGT-4
FGT-4 is a folate receptor β (FR-β) targeting chimeric molecule. FGT-4 is a TLR7 agonist. FGT-4 facilitates the secretion of iNOS and proinflammatory cytokine IL-6 associated with M1 macrophages and enhances the proliferation of cytotoxic CD8+ T cells. FGT-4 has anti-tumor activity in the 4T1 breast cancer mouse model. FGT-4 can be used for the study of cancer immunity. (Pink: target protein TLR7/8 agonist 1 ligand ; black: linker (HY-172936) ; blue: FR-β ligand (HY-172935) ).
Product Specifications
UNSPSC
12352211
Target
NO Synthase; PROTACs; Toll-like Receptor (TLR)
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer; Inflammation/Immunology
Smiles
NC(NC1=O)=NC2=C1C=C(CCCCC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CSSCCOC(NCC4=CC=C(CN5C6=C7C=CC=CC7=NC(N)=C6N=C5CCCC)C=C4)=O)=O)=O)N2
Molecular Formula
C50H57N11O9S2
Molecular Weight
1020.19
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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