FGT-4

FGT-4 is a folate receptor β (FR-β) targeting chimeric molecule. FGT-4 is a TLR7 agonist. FGT-4 facilitates the secretion of iNOS and proinflammatory cytokine IL-6 associated with M1 macrophages and enhances the proliferation of cytotoxic CD8+ T cells. FGT-4 has anti-tumor activity in the 4T1 breast cancer mouse model. FGT-4 can be used for the study of cancer immunity. (Pink: target protein TLR7/8 agonist 1 ligand (HY-103698) ; black: linker (HY-172936) ; blue: FR-β ligand (HY-172935) ) [1].

Product Specifications

UNSPSC

12352211

Target

NO Synthase; PROTACs; Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation; PROTAC

Field of Research

Cancer; Inflammation/Immunology

Smiles

NC(NC1=O)=NC2=C1C=C(CCCCC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(N[C@H](C(O)=O)CSSCCOC(NCC4=CC=C(CN5C6=C7C=CC=CC7=NC(N)=C6N=C5CCCC)C=C4)=O)=O)=O)N2

Molecular Formula

C50H57N11O9S2

Molecular Weight

1020.19

References & Citations

[1]Guo L, et al. Design and Synthesis of FR-β Targeting Chimeric Molecules for Reprogramming Tumor-Associated Macrophages Using 6-Substituted Pyrrolo[2,3-d]pyrimidines as Targeting Ligands. J Med Chem. 2025 Apr 24;68 (8) :8295-8309.