PVTX-405
PVTX-405 is a selective and oral active IKZF2 molecular glue degrader with a DC50 of 0.7 nM and a Dmax of 91%. PVTX-405 enhances degradation efficiency, significantly reduces off-target degradation, and alleviates hERG inhibition with IC50 of 48 µM. PVTX-405 significantly inhibits the growth of MC38 tumors, with greater synergistic anti-cancer efficacy in combination with immune checkpoint therapies (ICTs) (anti-PD1 or anti-LAG3) in the MC38 mouse tumor xenograft model using Crbn391V C57BL/6 mice[1].
Product Specifications
CAS Number
[2991021-08-8]
UNSPSC
12352005
Target
IKZF Family; Molecular Glues; Potassium Channel
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; PROTAC
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1C2=CC=C(C(OC3)=C2CN1[C@@H]4C(NC(CC4)=O)=O)C3(CC5)CCN5CC6=CC(C7=CN(N=C7)C)=CC=C6
Molecular Formula
C30H31N5O4
Molecular Weight
525.60
References & Citations
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-172930/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF2; Voltage-gated potassium channel
Available Sizes
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