FGFR-IN-20

Glu-IN-1 (compound AF1) is a covalent and selective FGFR2 inhibitor with an IC50 of 1.6 μM. Glu-IN-1 covalently modifies Glu489 in FGFR2[1].

Product Specifications

UNSPSC

12352211

Target

FGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CNC(C1=CC=C2C(N=C(N2CCCCCCCCCCNC(C3N=C3C4=CC=CC=C4)=O)C5=CC(C)=C(C(C)=C5)O)=C1)=O

Molecular Formula

C36H43N5O3

Molecular Weight

593.76

References & Citations

[1]Wu X, et al. Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads. J Am Chem Soc. 2025 May 7;147 (18) :15469-15481.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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