FGFR-IN-19

Arg-IN-1 is a selective Arginine (Arg) -targeting covalent inhibitor with IC50s of 9.7 nM and 30.4 nM for FGFR2 and FGFR3, respectively. Arg-IN-1 has the potential to avoid FGFR1/4-targeted toxicity as well as conquer acquired on-target resistance, potential for FGFR-targeting cancer therapy[1].

Product Specifications

UNSPSC

12352211

Target

FGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

COCCNC1=NC(NC2=NNC(C3=CC=CC=C3)=C2)=NC(NC4CC5(C4)CCN(CC5)C(CN6C=C(N=N6)COC7=CC=C(C=C7)C(C(O)O)=O)=O)=N1

Molecular Formula

C36H42N12O6

Molecular Weight

738.80

References & Citations

[1]Wu X, et al. Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads. J Am Chem Soc. 2025 May 7; 147 (18) :15469-15481.