FGFR-IN-18
FGFR-IN-18 (Compound KF7) is a lysine-targeting FGFR covalent inhibitor, with IC50s of: 1.1 nM for FGFR2, 1.3 nM for FGFR1, 31.5 nM for FGFR4. FGFR-IN-18 also has affinity for FGFR3 (inhibition rate of 52% at 10 nM) . FGFR-IN-18 covalently modifies Lys485 (an reactive site of FGFRs) [1].
Product Specifications
UNSPSC
12352211
Target
FGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=CC(CCC2=CC(NC3=NC(NCC4=CC=CC(CNC5=C(C(C5=O)=O)OC)=C4)=NC(NCCOC)=N3)=NN2)=CC(OC)=C1
Molecular Formula
C32H37N9O6
Molecular Weight
643.69
References & Citations
[1]Wu X, et al. Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads. J Am Chem Soc. 2025 May 7;147 (18) :15469-15481.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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