Rho GTPase inhibitor 1
Rho GTPase inhibitor 1 (compound 7) is a potent Rho GTPase inhibitor. Rho GTPase inhibitor 1 exhibits high affinity on Cdc42, Rac1 and RhoA with KDs of 151, 352, and 232 μM, respectively. Rho GTPase inhibitor 1 reduces cell migration on glioma cell line[1].
Product Specifications
CAS Number
[1309252-99-0]
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Field of Research
Cancer
Smiles
NCC1OC2=C(C=CC=C2C3=CN=CC4=C3C=CC=C4)C1
Molecular Formula
C18H16N2O
Molecular Weight
276.33
References & Citations
[1]Parise A, et al. Identification of a new small Rho GTPase inhibitor effective in glioblastoma human cells. Eur J Med Chem. 2025 Aug 5;292:117704.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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