P53 Stabilizer 2
P53 Stabilizer 2 (Compound 17a16) is a p53 stabilizer. p53 Stabilizer 2 induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells. p53 Stabilizer 2 induces mitochondrial stress and activates two checkpoint pathways: NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. p53 Stabilizer 2 inhibits tumor growth in p53-deficient xenograft model[1].
Product Specifications
CAS Number
[2531685-87-5]
UNSPSC
12352005
Target
Apoptosis; Checkpoint Kinase (Chk) ; MDM-2/p53
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1O[C@H]([C@@H]2N(C)CCC3=C(C[Se]C4CCCCCC4)C5=C(OCO5)C(OC)=C23)C6=C1C(OC)=C(OC)C=C6
Molecular Formula
C30H37NO7Se
Molecular Weight
602.58
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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