ACLY-IN-1

ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity (IC50 = 8.3 nM) and high binding affinity (KD = 72.0 nM) to ACLY. ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect[1].

Product Specifications

CAS Number

[2897695-26-8]

UNSPSC

12352101

Target

ATP Citrate Lyase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cardiovascular Disease; Metabolic Disease

Smiles

ClC1=CC2=CC(S(=O)(NC3=CC(C4=C(C=CC(Br)=C4)CNC2=O)=C(C=C3F)F)=O)=C1O

Molecular Formula

C20H12BrClF2N2O4S

Molecular Weight

529.74

References & Citations

[1]Zang Y, et.al., Design, synthesis, and Biological evaluation of novel macrocyclic derivatives as potent ATP-citrate lyase inhibitors. Eur J Med Chem. 2025 Aug 5;292:117684.