ACLY-IN-1
ACLY-IN-1 is an orally active ACLY inhibitor. ACLY-IN-1 exhibits potent ACLY inhibitory activity (IC50 = 8.3 nM) and high binding affinity (KD = 72.0 nM) to ACLY. ACLY-IN-1 demonstrates good pharmacokinetic profiles and a potent in vivo hypolipidemic effect[1].
Product Specifications
CAS Number
2897695-26-8
UNSPSC
12352101
Target
ATP Citrate Lyase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cardiovascular Disease; Metabolic Disease
Smiles
ClC1=CC2=CC(S(=O)(NC3=CC(C4=C(C=CC(Br)=C4)CNC2=O)=C(C=C3F)F)=O)=C1O
Molecular Formula
C20H12BrClF2N2O4S
Molecular Weight
529.74
References & Citations
[1]Zang Y, et.al., Design, synthesis, and Biological evaluation of novel macrocyclic derivatives as potent ATP-citrate lyase inhibitors. Eur J Med Chem. 2025 Aug 5;292:117684.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC741429-100 1x 100 µL
E-Cadherin / CD324 (Intercellular Junction Marker) (4A2), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC051037-500 1x 500 µL
CD44 Standard (DF1485), CF405M conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC680158-100 1x 100 µL
Cytokeratin 17 (E3), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881620-100 1x 100 µL
CD10 (Membrane Metalloendopeptidase) (MME/1620), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC940211-500 1x 500 µL
HCG-beta (hCGb/459), CF594 conjugate, 0.1mg/mL
Sign In for Pricing
View Details