SHP2-IN-37
SHP2-IN-37 (compound C5) is a potent and selective SHP2 allosteric inhibitor with an IC50 of 0.023 μM. SHP2-IN-37 exhibits antiproliferative effect on KYSE-520 and MV-411 cells with IC50s of 6.97 and 0.67 μM, respectively[1]
Product Specifications
UNSPSC
12352005
Target
SHP2
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
96.36
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(Cl)C(SC2=CN=C(N(CC3)CCC43[C@H](N)[C@H](C)OC4)C=[N+]2[O-])=CC=C1
Molecular Formula
C19H22Cl2N4O2S
Molecular Weight
441.37
References & Citations
[1]Wang X, et al. Design, synthesis, anticancer activity evaluation and molecular dynamics study of pyrazine N-oxide-based SHP2 allosteric inhibitors. Eur J Med Chem. 2025 Apr 30;293:117687.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K1803007 1.0 µg DNA
RCBTB2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
Sign In for Pricing
View Details