SHP2-IN-37
SHP2-IN-37 (compound C5) is a potent and selective SHP2 allosteric inhibitor with an IC50 of 0.023 μM. SHP2-IN-37 exhibits antiproliferative effect on KYSE-520 and MV-411 cells with IC50s of 6.97 and 0.67 μM, respectively[1]
Product Specifications
UNSPSC
12352005
Target
SHP2
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Purity
96.36
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(Cl)C(SC2=CN=C(N(CC3)CCC43[C@H](N)[C@H](C)OC4)C=[N+]2[O-])=CC=C1
Molecular Formula
C19H22Cl2N4O2S
Molecular Weight
441.37
References & Citations
[1]Wang X, et al. Design, synthesis, anticancer activity evaluation and molecular dynamics study of pyrazine N-oxide-based SHP2 allosteric inhibitors. Eur J Med Chem. 2025 Apr 30;293:117687.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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