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MTHFD2-IN-6

MTHFD2-IN-6 (compound 41) is a potent and selective MTHFD2 inhibitor. MTHFD2-IN-6 inhibits MTHFD1 and MTHFD2 with IC50s of 19.05 and 1.46 μM, respectively[1].

Product Specifications

CAS Number

3077252-76-4

UNSPSC

12352005

Target

Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

O=C(C1=C(O)C=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(Cl)C(OC)=C2

Molecular Formula

C21H21ClO5

Molecular Weight

388.84

References & Citations

[1]Hu Y, et al. Hit to lead optimization of isopentenyl chalcones as novel MTHFD2 inhibitors for cancer treatment: design, synthesis, in-vitro, in-vivo and in-silico studies. Eur J Med Chem. 2025 Aug 5;292:117703.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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