RIPK3-IN-5
RIPK3-IN-5 (compound 32) is a potent RIPK3 inhibitor with an IC50 of 27 nM. RIPK3-IN-5 also inhibits necroptosis with an EC50 of 0.45 μM[1].
Product Specifications
UNSPSC
12352101
Target
Necroptosis; RIP kinase
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Smiles
CN1CCN(C2=CC=C(C3=CC4=NC=NC(NC5=C(F)C=CC=C5F)=C4C=C3)C=N2)CC1
Molecular Formula
C24H22F2N6
Molecular Weight
432.47
References & Citations
[1]Parry C W, et al. Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras[J]. Journal of Medicinal Chemistry, 2025, 68 (9) : 9129-9161.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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