Nav1.8-IN-16
Nav1.8-IN-16 (Compound (R) -40) is an orally active and selective hNaV 1.8 inhibitor (IC50: 5.9 nM) . Nav1.8-IN-16 exerts analgesic effects by blocking NaV1.8 channels without significantly affecting other NaV subtypes or hERG channels. Nav1.8-IN-16 exhibits dose-dependent analgesic effects in postoperative pain and inflammatory pain models and can be used in pain-related research[1].
Product Specifications
UNSPSC
12352005
Target
Sodium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(NC1=CC=C(F)C(C(N)=O)=C1)C2=CC(Cl)=C(C(F)(F)F)C=C2[C@H]3CCOC4=C3C=CC=C4F
Molecular Formula
C24H16ClF5N2O3
Molecular Weight
510.84
References & Citations
[1]Li N, et al. Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties. Eur J Med Chem. 2025 May 6;293:117697.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nav1.8
Available Sizes
Frequently Asked Questions
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